Journal article
A review and analysis of the Chinese hamster ovary/hypoxanthine guanine phosphoribosyl transferase assay to determine the mutagenicity of chemical agents. A report of phase III of the U.S. environmental protection agency Gene-Tox program
Abstract
Published literature on the Chinese hamster ovary cell/hypoxanthine guanine phosphoribosyl transferase (CHO/HGPRT) assay from mid-1979 through June 1986 was reviewed and evaluated. Data from the papers considered acceptable include test results on 121 chemicals belonging to 25 chemical classes. A total of 87 chemicals were evaluated positive, 3 negative, and 31 inconclusive. Mutagenicity data on 49 of the 121 chemicals evaluated could also be …
Authors
Li AP; Gupta RS; Heflich RH; Wassom JS
Journal
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 196, No. 1, pp. 17–36
Publisher
Elsevier
Publication Date
July 1988
DOI
10.1016/0165-1110(88)90026-7
ISSN
0027-5107