Journal article
Reversal of suppression of lymphokine-activated killer cells by transforming growth factor-β in ovarian carcinoma ascitic fluid requires interleukin-2 combined with anti-CD3 antibody
Abstract
Ascitic fluid from human ovarian carcinoma (AF) has been shown to inhibit IL-2-induced lymphokine-activated killer (LAK) cell generation from peripheral blood mononuclear cells (PBMC) resulting from the presence of biologically active transforming growth factor-beta (TGF-beta). A 50% concentration of AF completely suppressed the LAK response to 100 units IL-2/ml and only partial reversal (less than 50%) could be achieved by increasing the IL-2 …
Authors
Hirte HW; Clark DA; O'Connell G; Rusthoven J; Mazurka J
Journal
Cellular Immunology, Vol. 142, No. 1, pp. 207–216
Publisher
Elsevier
Publication Date
June 1992
DOI
10.1016/0008-8749(92)90281-s
ISSN
0008-8749