Journal article
Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease
Abstract
BACKGROUND: In observational studies, lower homocysteine levels are associated with lower rates of coronary heart disease and stroke. Folic acid and vitamins B6 and B12 lower homocysteine levels. We assessed whether supplementation reduced the risk of major cardiovascular events in patients with vascular disease.
METHODS: We randomly assigned 5522 patients 55 years of age or older who had vascular disease or diabetes to daily treatment either …
Authors
Lonn E; Yusuf S; Arnold MJ; Sheridan P; Pogue J; Micks M; McQueen MJ; Probstfield J; Fodor G; Held C
Journal
The New England Journal of Medicine, Vol. 354, No. 15, pp. 1567–1577
Publisher
Massachusetts Medical Society
Publication Date
April 13, 2006
DOI
10.1056/nejmoa060900
ISSN
0028-4793