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Pre- and postjunctional effects of a thromboxane...

Journal article

Pre- and postjunctional effects of a thromboxane mimetic in canine bronchi

Abstract

Thromboxane A2 is believed to participate in causation of hyperreactivity of airway smooth muscle (ASM). We therefore investigated the effects of a thromboxane mimetic (U-46619) on isolated ring segments of canine bronchial ASM (3rd to 5th order). U-46619 (10(-9)-10(-5) M) was found to elicit tonic contraction, membrane depolarization, and oscillations in membrane potential. These effects were sensitive to blockade of thromboxane receptors …

Authors

Janssen LJ; Daniel EE

Journal

American Journal of Physiology-Lung Cellular and Molecular Physiology, Vol. 261, No. 4, pp. L271–L276

Publisher

American Physiological Society

Publication Date

October 1, 1991

DOI

10.1152/ajplung.1991.261.4.l271

ISSN

1040-0605

Associated Experts

Luke Jeffrey Janssen

Professor Emeritus, Faculty of Health Sciences

Labels

Medical Subject Headings (MeSH)

15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid Animals Bronchi Carbazoles Dogs Electrophysiology In Vitro Techniques Muscle, Smooth Neuromuscular Junction Prostaglandin Endoperoxides, Synthetic Thromboxane A2 Thromboxanes

Fields of Research (FoR)

3201 Cardiovascular medicine and haematology 3208 Medical physiology

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