Journal article
Identification of mechanisms and sites of actions of mu and delta opioid receptor activation in the canine intestine.
Abstract
Perfusion with ([N-Me-Phe3,D-Pro4]morphiceptin (PL017)), [D-Pen2,5]enkephalin (DPDPE) and MEt5 and Leu5 enkephalin induced circular muscle contractions and decreased immunoreactive vasoactive intestinal polypeptide (VIP) venous output in canine ileal segments. Motility and VIP responses to PL017 were abolished by the mu antagonist CTAP (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2) and unchanged by the delta antagonist ICI 174,864 …
Authors
Fox-Threlkeld JE; Daniel EE; Christinck F; Hruby VJ; Cipris S; Woskowska Z
Journal
Journal of Pharmacology and Experimental Therapeutics, Vol. 268, No. 2, pp. 689–700
Publisher
Elsevier
Publication Date
February 1994
DOI
10.1016/s0022-3565(25)38996-2
ISSN
0022-3565