An inherited pericentric chromosomal inversion (46, inv3 [p-q+]) associated with skeletal anomalies

A family is described in which the propositus and his mother possess identical skeletalanomalies of the fingers and toes. Cytogenetic investigation revealed an abnormal No. 3 chromosome in both peripheral lymphocytes and fibroblasts of these individuals On the basis of morphologic, autoradiographic, and measurement data, this chromosome is interpreted as representing a pericentric inversion of a No. 3.