Microangiopathic Haemolytic Anaemia: the Experimental Production of Haemolysis and Red‐Cell Fragmentation by Defibrination in Vivo

S ummary . In rabbits transient haemoglobinaemia accompanied rapid defibrination produced by the purified coagulant fraction of the venom of the Malayan pit‐viper, Agkistrodon rhodostoma . The degree of haemoglobinaemia was dependent upon the rate of defibrination. Inhibition of fibrinolysis resulted in the persistence of the haemoglobinaemia after venom defibrination. Irradiation to produce thrombocytopenia or anticoagulation enabled these …