Journal article
Life‐threatening hemolytic anemia due to an autoanti‐Pr cold agglutinin: evidence that glycophorin A antibodies may induce lipid bilayer exposure and cation permeability independent of agglutination
Abstract
BACKGROUND: The hemoglobin of a 29-year-old man fell below 35 g/L over 5 days, despite 14 units of red blood cells (RBCs), due to an anti-Pr cold agglutinin (CA). His hemolytic anemia necessitated respiratory support in intensive care for 4 weeks.
STUDY DESIGN AND METHODS: The hemolysis was investigated by the effects on blood group-compatible RBCs of this anti-Pr and an anti-I CA and of a rabbit anti-human glycophorin A (GPA) immunoglobulin G …
Authors
Brain M; Ruether B; Valentine K; Brown C; Keurs HT
Journal
Transfusion, Vol. 50, No. 2, pp. 292–301
Publisher
Wiley
Publication Date
February 2010
DOI
10.1111/j.1537-2995.2009.02445.x
ISSN
0041-1132
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultAnemia, Hemolytic, AutoimmuneAntibodies, MonoclonalAntibodies, Monoclonal, Murine-DerivedBacteriocinsBlood Group AntigensBlood TransfusionCalciumCell Membrane PermeabilityCell ShapeCombined Modality TherapyCryoglobulinsErythrocyte MembraneGlycophorinsHemolysisHumansImmunoglobulin GImmunoglobulin MImmunoglobulins, IntravenousImmunosuppressive AgentsMaleMethylprednisoloneModels, ImmunologicalMultiple SclerosisPeptides, CyclicPhosphatidylethanolaminesPlasmapheresisRituximab