Journal article
Cellular and nerve regeneration within a biosynthetic extracellular matrix for corneal transplantation
Abstract
Our objective was to determine whether key properties of extracellular matrix (ECM) macromolecules can be replicated within tissue-engineered biosynthetic matrices to influence cellular properties and behavior. To achieve this, hydrated collagen and N-isopropylacrylamide copolymer-based ECMs were fabricated and tested on a corneal model. The structural and immunological simplicity of the cornea and importance of its extensive innervation for …
Authors
Li F; Carlsson D; Lohmann C; Suuronen E; Vascotto S; Kobuch K; Sheardown H; Munger R; Nakamura M; Griffith M
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, No. 26, pp. 15346–15351
Publisher
Proceedings of the National Academy of Sciences
Publication Date
December 23, 2003
DOI
10.1073/pnas.2536767100
ISSN
0027-8424