Solid-phase analytical derivatization: enhancement of sensitivity and selectivity of analysis

Analytical derivatizations enhance the sensitivity and selectivity of determinations for organic compounds. Classical techniques are often based on solution chemistry. Most modern sample preparation techniques, however, are based on solid-phase extractions. Solid-phase analytical derivatization bridges this gap and facilitates sample preparation by combining the isolation step with the derivatization. The solid-phase retains both reagents and derivatized analytes and often permits facile separation of excess reagent or selective elution of the desired products. The most recent solid-phase extraction techniques have been used in conjunction with analytical derivatization to automate the analysis. In this review, analytical derivatizations are presented as functional group analysis.