Combination therapy of cyclosporine with methotrexate and gold in rheumatoid arthritis (2 pilot studies). Journal Articles uri icon

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  • OBJECTIVE: To evaluate the efficacy and toxicity of cyclosporine A (CyA) in combination with gold and methotrexate (MTX) in patients with rheumatoid arthritis (RA). METHODS: Twenty patients with RA with partial response to oral MTX and 20 patients with partial response to im gold had CyA added to their regimen for 6 months, withdrawn over 2 months and the patients monitored for 4 months. RESULTS: There was a significant improvement in joint count, joint score, joint swelling, grip strength and joint pain in patients taking the combination with no significant increase in adverse reactions. CONCLUSION: CyA in combination with gold or MTX may, over a 6 month period, increase efficacy in patients with refractory RA without significant increase in toxicity.


  • Bensen, W
  • Tugwell, P
  • Roberts, RM
  • Ludwin, David
  • Ross, H
  • Grace, E
  • Gent, M

publication date

  • November 1994