AIT-082 as a potential neuroprotective and regenerative agent in stroke and central nervous system injury Academic Article uri icon

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abstract

  • The synthetic purine 4-[[3-(1,6 dihydro-6-oxo-9-purin-9-yl)-1-oxypropyl] amino] benzoic acid (AIT-082, Neotrofin, leteprinim potassium) possesses several biological properties of note: it stimulates outgrowth of neurites from PC12 cells and neurones, stimulates synthesis and/or release of neurotrophic factors from astrocytes, enhances nerve fibre regeneration in vivo and enhances of memory in animals and humans. AIT-082 also protects against glutamate neurotoxicity in vitro and in vivo, which has led to successful tests of AIT-082 in animal models of acute central nervous system injury. In such cases, AIT-082 probably functions by both acutely reducing glutamate excitotoxicity and, over a longer period, by enhancing neuronal sprouting and functional recovery.

authors

  • Rathbone, Michel Piers
  • Middlemiss, Pamela J
  • Crocker, Candice E
  • Glasky, Michelle S
  • Juurlink, Bernhard HJ
  • Ramirez, Julio J
  • Ciccarelli, Renata
  • Di Iorio, Patrizia
  • Caciagli, Francesco

publication date

  • August 1999