selected scholarly activity
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conferences
- How does extracellular guanosine regulate some of its biological effects?. Purinergic Signalling. 736-736. 2014
- Putative involvement of novel receptors in the effects produced by guanine and its derivatives at the central nervous system. Purinergic Signalling. 736-736. 2014
- Guanosine protects against reperfusion injury in rat brains after ischemic stroke. Stroke. E159-E159. 2012
- Body-weight supported treadmill training in progressive multiple sclerosis: effects on physical function, fatigue, quality of life and brain-derived neurotrophic factor. Multiple Sclerosis. 1019-1019. 2010
- Distribution and metabolism of intraperitoneally administered guanosine in rat. Purinergic Signalling. 61-62. 2010
- The effects of treadmill training on functional ability, quality of life and fatigue in primary-progressive multiple sclerosis. Multiple Sclerosis. 1409-1409. 2009
- AIT-082 and methylprednisolone singly, but not in combination, enhance functional and histological improvement after acute spinal injury in rats.. Journal of Neurotrauma. 1305-1305. 2004
- Guanosine induces remyelination and improves functional outcome after spinal cord injury. Journal of Neurotrauma. 1305-1305. 2004
- Guanosine promotes remyelination and functional recovery in chronic spinal. Journal of Neurotrauma. 1081-1081. 2003
- Glial cells release ATP and cys-leukotrienes: Modulation by P2 and cys-LT1 receptors. Glia. S32-S32. 2002
- Purine nucleosides protect injured neurons and stimulate neuronal regeneration by intracellular and membrane receptor‐mediated mechanisms. Drug Development Research. 303-315. 2001
- Physiology and pharmacology of natural and synthetic nonadenine-based purines in the nervous system. Drug Development Research. 356-372. 1998
- AIT-082, a unique purine derivative with neuroregenerative properties. Naunyn-Schmiedeberg's Archives of Pharmacology. R49-R49. 1998
- AN ANALYSIS OF POSTOPERATIVE CONTRAST ENHANCEMENT AND OTHER CT ARTIFACTS IN BRAIN-TUMOR PATIENTS. Journal of Neuro-Oncology. 273-273. 1984
- ANALYSIS OF POSTOPERATIVE CT SCANS IN BRAIN-TUMOR PATIENTS. Canadian Journal of Neurological Sciences. 324-324. 1984
- CISPLATINUM CHEMOTHERAPY FOR RECURRENT BRAIN-TUMORS. Journal of Neuro-Oncology. 287-287. 1984
- PHLORETIN-SENSITIVE LITHIUM TRANSPORT IN ERYTHROCYTES OF AFFECTIVELY ILL PATIENTS - INTRA-INDIVIDUAL REPRODUCIBILITY. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 318-319. 1981
- THE EFFECT OF PHENYTOIN ON MEMBRANE-PROTEIN PHOSPHORYLATION IN PATIENTS WITH MYOTONIC MUSCULAR-DYSTROPHY. Canadian Journal of Neurological Sciences. 125-125. 1980
- DIFFERENTIAL EFFECTS OF PRENATAL NEUROLEPTIC TREATMENT ON DOPAMINE RECEPTORS AND DOPAMINE-SENSITIVE ADENYLATE-CYCLASE ACTIVITY IN RAT STRIATUM. Integrative and Comparative Biology. 980-980. 1979
- NEUROTROPHIC-LIKE EFFECTS OF BOVINE PITUITARY FIBROBLAST GROWTH-FACTOR ON REGENERATING LIMB BLASTEMATA AND SKELETAL-MUSCLES OF NEWTS INVITRO. Integrative and Comparative Biology. 925-925. 1979
- ALTERED CHOLESTEROL CONTENT AND INCREASED GROWTH-RATE OF FIBROBLASTS FROM CHICKENS WITH HEREDITARY MUSCULAR-DYSTROPHY. In Vitro. 157-157. 1977
- ROLE OF CYCLIC-AMP AND CYCLIC-GMP IN REGULATION OF CHOLINESTERASE IN DENERVATED AMPHIBIAN MUSCLES CULTURED INVITRO. In Vitro. 157-157. 1977
- ORGAN INITIATION IN TOBACCO CALLUS-CULTURES - ROLE OF STARCH HYDROLYSIS. In Vitro. 333-333. 1976
- ROLE OF CYCLIC-AMP IN NEUROTROPHIC REGULATION OF MUSCLE CHOLINESTERASE. The FASEB Journal. 697-697. 1976
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journal articles
- RETRACTED ARTICLE: Modulation of the TGF-β1-induced epithelial to mesenchymal transition (EMT) mediated by P1 and P2 purine receptors in MDCK cells. Purinergic Signalling. 13:429-442. 2017
- Evidence for purine nucleoside phosphorylase (PNP) release from rat C6 glioma cells. Journal of Neurochemistry. 141:208-221. 2017
- Exercise Training in Progressive Multiple Sclerosis. International Journal of MS Care. 18:221-229. 2016
- A review of the neuro- and systemic inflammatory responses in post concussion symptoms: Introduction of the “post-inflammatory brain syndrome” PIBS. Brain, Behavior, and Immunity. 46:1-16. 2015
- Retraction: Guanosine Inhibits CD40 Receptor Expression and Function Induced by Cytokines and β Amyloid in Mouse Microglia Cells. Journal of Immunology. 194:1381-1381. 2015
- Postanoxic Myoclonus: Two Case Presentations and Review of Medical Management. Archives of Physical Medicine and Rehabilitation. 95:588-590. 2014
- Guanosine Protects Glial Cells Against 6-Hydroxydopamine Toxicity. Advances in Experimental Medicine and Biology. 837:23-33. 2014
- Guanosine protects against reperfusion injury in rat brains after ischemic stroke. Journal of Neuroscience Research. 91:262-272. 2013
- Effects of a novel herbal formulation JSK on acute spinal cord injury in rats. Restorative Neurology and Neuroscience. 31:597-617. 2013
- Guanosine promotes proliferation of neural stem cells through cAMP-CREB pathway.. Journal of Biological Regulators and Homeostatic Agents. 27:673-680. 2013
- Protective activity of guanosine in an in vitro model of Parkinson's disease. Panminerva Medica. 54:43-51. 2012
- Protective activity of guanosine in an in vitro model of Parkinson's disease.. Panminerva Medica. 54:43-51. 2012
- Enteric glia mediate neuronal outgrowth through release of neurotrophic factors.. Neural Regeneration Research. 7:2165-2175. 2012
- Tissue distribution and metabolism of guanosine in rats following intraperitoneal injection (vol 26, pg 51, 2012). Journal of Biological Regulators and Homeostatic Agents. 26. 2012
- Tissue distribution and metabolism of guanosine in rats following intraperitoneal injection.. Journal of Biological Regulators and Homeostatic Agents. 26:51-65. 2012
- Systemic administration of guanosine promotes functional and histological improvement following an ischemic stroke in rats. Brain Research. 1407:79-89. 2011
- Effects of 12 Weeks of Supported Treadmill Training on Functional Ability and Quality of Life in Progressive Multiple Sclerosis: A Pilot Study. Archives of Physical Medicine and Rehabilitation. 92:31-36. 2011
- Guanosine-induced decrease in side population of lung cancer cells: lack of correlation with ABCG2 expression.. Journal of Biological Regulators and Homeostatic Agents. 24:19-25. 2010
- Locally transplanted enteric glia improve functional and structural recovery in a rat model of spinal cord injury. Neural Regeneration Research. 4:710-716. 2009
- Remyelination after chronic spinal cord injury is associated with proliferation of endogenous adult progenitor cells after systemic administration of guanosine. Purinergic Signalling. 4:61-71. 2008
- Neuroprotective effects of guanosine on stroke models in vitro and in vivo. Neuroscience Letters. 431:101-105. 2008
- Neuroprotective effects of guanosine on stroke models in vitro and in vivo. Neuroscience Letters. 431:101-105. 2008
- Prognostic indicators in metastatic spinal cord compression: using functional independence measure and Tokuhashi scale to optimize rehabilitation planning. Spinal Cord. 45:671-677. 2007
- Guanosine reduces apoptosis and inflammation associated with restoration of function in rats with acute spinal cord injury. Purinergic Signalling. 3:411-421. 2007
- MPP+-induced cytotoxicity in neuroblastoma cells: Antagonism and reversal by guanosine. Purinergic Signalling. 3:399-409. 2007
- Guanosine inhibits CD40 receptor expression and function induced by cytokines and β amyloid in mouse microglia cells. Journal of Immunology. 178:5399-5400. 2007
- Activation of P2X7 Receptors Stimulates the Expression of P2Y2 Receptor mRNA in Astrocytes Cultured from Rat Brain. International Journal of Immunopathology and Pharmacology. 20:301-316. 2007
- Guanosine Inhibits CD40 Receptor Expression and Function Induced by Cytokines and β Amyloid in Mouse Microglia Cells. Journal of Immunology. 178:720-731. 2007
- Guanosine effect on cholesterol efflux and apolipoprotein E expression in astrocytes. Purinergic Signalling. 2:637-649. 2006
- Non-adenine based purines accelerate wound healing. Purinergic Signalling. 2:651-661. 2006
- P2Y2 Receptor Up-Regulation Induced by Guanosine or UTP in Rat Brain Cultured Astrocytes. International Journal of Immunopathology and Pharmacology. 19:293-308. 2006
- Nucleoside transporter expression and function in cultured mouse astrocytes. Glia. 52:25-35. 2005
- P2X7Receptor Activation in Rat Brain Cultured Astrocytes Increases the Biosynthetic Release of Cysteinyl Leukotrienes. International Journal of Immunopathology and Pharmacology. 18:417-430. 2005
- Guanosine stimulates neurite outgrowth in PC12 cells via activation of heme oxygenase and cyclic GMP. Purinergic Signalling. 1:161-172. 2005
- Acceleration of blood-brain barrier formation after transplantation of enteric glia into spinal cords of rats. Experimental Brain Research. 162:56-62. 2005
- Ait-082 and Methylprednisolone Singly, but Not in Combination, Enhance Functional and Histological Improvement after Acute Spinal Cord Injury in Rats. International Journal of Immunopathology and Pharmacology. 17:353-366. 2004
- The antiapoptotic effect of guanosine is mediated by the activation of the PI 3‐kinase/AKT/PKB pathway in cultured rat astrocytes. Glia. 46:356-368. 2004
- Guanosine protects SH-SYSY cells against beta-amyloid-induced apoptosis. NeuroReport. 15:833-836. 2004
- Guanosine protects SH-SY5Y cells against β-amyloid-induced apoptosis. NeuroReport. 15:833-836. 2004
- Cooperation in signal transduction of extracellular guanosine 5′ triphosphate and nerve growth factor in neuronal differentiation of PC12 cells. Neuroscience. 128:697-712. 2004
- Guanosine promotes myelination and functional recovery in chronic spinal injury. NeuroReport. 14:2463-2467. 2003
- Enteric glia promote functional recovery of CTM reflex after dorsal root transection. NeuroReport. 14:1301-1304. 2003
- Enteric glia promote functional recovery of CTM reflex after dorsal root transection. NeuroReport. 14:1301-1304. 2003
- Enteric glia promote regeneration of transected dorsal root axons into spinal cord of adult rats. Experimental Neurology. 181:79-83. 2003
- Glial cells express multiple ATP binding cassette proteins which are involved in ATP release. NeuroReport. 13:1789-1792. 2002
- Mechanisms of apoptosis induced by purine nucleosides in astrocytes. Glia. 38:179-190. 2002
- Specific [3H]‐guanosine binding sites in rat brain membranes. British Journal of Pharmacology. 135:969-976. 2002
- A METHOD FOR PURIFYING ENTERIC GLIA FROM RAT MYENTERIC PLEXUS. In Vitro Cellular and Developmental Biology - Animal. 38:188-188. 2002
- Guanosine‐induced increase in free cytosolic calcium concentration in mouse astrocytes in primary cultures: Does it act on an A3 adenosine receptor?. Journal of Neuroscience Research. 65:184-189. 2001
- Involvement of astrocytes in purine‐mediated reparative processes in the brain. International Journal of Developmental Neuroscience. 19:395-414. 2001
- AIT-082 Is Neuroprotective against Kainate-Induced Neuronal Injury in Rats. Experimental Neurology. 169:392-399. 2001
- Extracellular guanosine 5′ triphosphate enhances nerve growth factor-induced neurite outgrowth via increases in intracellular calcium. Neuroscience. 96:817-824. 2000
- Cultured astrocyte proliferation induced by extracellular guanosine involves endogenous adenosine and is raised by the co-presence of microglia. Glia. 29:202-211. 2000
- Cultured astrocyte proliferation induced by extracellular guanosine involves endogenous adenosine and is raised by the co-presence of microglia.. Glia. 29:202-211. 2000
- Trophic effects of purines in neurons and glial cells. Progress in Neurobiology. 59:663-690. 1999
- AIT-082 as a potential neuroprotective and regenerative agent in stroke and central nervous system injury. Expert Opinion on Investigational Drugs. 8:1255-1262. 1999
- Rat cultured astrocytes release guanine-based purines in basal conditions and after hypoxia/hypoglycemia. Glia. 25:93-98. 1999
- Rat cultured astrocytes release guanine‐based purines in basal conditions and after hypoxia/hypoglycemia. Glia. 25:93-98. 1999
- The Trophic Effects of Purines and Purinergic Signaling in Pathologic Reactions of Astrocytes. Alzheimer Disease and Associated Disorders. 12:S36-S36. 1998
- Altered Guanosine and Guanine Concentrations in Rabbit Striatum Following Increased Dopamine Turnover. Brain Research Bulletin. 45:297-299. 1998
- AIT-082, a novel purine derivative with neuroregenerative properties. Expert Opinion on Investigational Drugs. 6:1413-1417. 1997
- Nitric oxide donors enhance neurotrophin-induced neurite outgrowth through a cGMP-dependent mechanism. Journal of Neuroscience Research. 47:427-439. 1997
- Neurite outgrowth in PC12 cells is enhanced by guanosine through both cAMP-dependent and -independent mechanisms. Neuroscience Letters. 220:175-178. 1996
- Rat astroglial P2Z (P2X7) receptors regulate intracellular calcium and purine release. NeuroReport. 7:2533-2538. 1996
- A randomized trial to assess the efficacy of surgery in addition to radiotherapy in patients with a single cerebral metastasis. Cancer. 78:1470-1476. 1996
- GTP and guanosine synergistically enhance NGF‐induced neurite outgrowth from PC12 cells. International Journal of Developmental Neuroscience. 14:19-34. 1996
- Trophic actions of extracellular nucleotides and nucleosides on glial and neuronal cells. Trends in Neurosciences. 19:13-18. 1996
- AIT-082, a unique purine derivative, enhances nerve growth factor mediated neurite outgrowth from PC12 cells. Neuroscience Letters. 199:131-134. 1995
- Extracellular guanosine and guanosine-5′-triphosphate increase: NGF synthesis and release from cultured mouse neopallial astrocytes. Brain Research. 677:152-156. 1995
- Stimulation of reactive astrogliosis in vivo by extracellular adenosine diphosphate or an adenosine A2 receptor agonist. Journal of Neuroscience Research. 38:399-406. 1994
- Primidone and rapid cycling affective disorders. The Lancet. 342:925-925. 1993
- Stimulation of astrocyte proliferation by purine and pyrimidine nucleotides and nucleosides. Glia. 7:176-182. 1993
- Guanosine enhances NGF-stimulated neurite outgrowth in PC12 cells. NeuroReport. 3:997-1000. 1992
- Purine nucleosides and nucleotides stimulate proliferation of a wide range of cell types. In vitro cellular & developmental biology : journal of the Tissue Culture Association. 28:529-536. 1992
- Extracellular purine nucleosides stimulate cell division and morphogenesis: Pathological and physiological implications. Medical Hypotheses. 37:232-240. 1992
- Purinergic stimulation of cell division and differentiation: Mechanisms and pharmacological implications. Medical Hypotheses. 37:213-219. 1992
- Astroglial growth factors in normal human brain and brain tumors: comparison with embryonic brain. Journal of Neuro-Oncology. 12:205-218. 1992
- Adenosine and its nucleotides stimulate proliferation of chick astrocytes and human astrocytoma cells. Neuroscience Research. 13:1-17. 1992
- Extracellular guanosine increases astrocyte cAMP. NeuroReport. 2:661-664. 1991
- Purinergic stimulation of astroblast proliferation: Guanosine and its nucleotides stimulate cell division in chick astroblasts. Journal of Neuroscience Research. 28:442-455. 1991
- Phase II Study of Trimetrexate in Recurrent Anaplastic Glioma: National Cancer Institute of Canada Clinical Trials Group Study. Canadian Journal of Neurological Sciences. 17:21-23. 1990
- Reply. Annals of Neurology. 19:611-612. 1986
- Partial purification of a low‐molecular‐weight growth factor from chicken brain. Journal of Cellular Physiology. 124:467-473. 1985
- Postoperative contrast enhancement in patients with brain tumor. Annals of Neurology. 17:570-572. 1985
- Post-Surgical Contrast Enhancement Mimicking Residual Brain Tumour. Canadian Journal of Neurological Sciences. 12:75-75. 1985
- Erythrocyte lithium efflux in bipolar patients and control subjects: The question of reproducibility. Psychiatry Research. 13:175-185. 1984
- Accelerated loss of motor neurons in the brachial lateral motor column in muscular dystrophic chicks. Developmental Brain Research. 14:271-277. 1984
- Accelerated loss of motor neurons in the brachial lateral motor column in muscular dystrophic chicks.. Brain Research. 316:271-277. 1984
- Erythrocyte Lithium Transport in Bipolar Affective Disorders. Neuropsychobiology. 12:86-92. 1984
- Phloretin-Inhibited Lithium Efflux: Does Measurement Contribute to Better Management of Bipolar Patients?. Canadian Journal of Psychiatry. 28:156-157. 1983
- Levels of cyclic GMP and cyclic AMP in regenerating forelimbs of adult newts following denervation. Journal of Experimental Zoology. 225:175-185. 1983
- Cyclic AMP and cyclic GMP levels in regenerating adult newt forelimbs following anaesthetization. Canadian Journal of Zoology. 60:976-983. 1982
- Nerve trophic effects: Partial purification from chick embryo brains of proteins that stimulate protein synthesis in cultured newt blastemata. Experimental Neurology. 73:558-570. 1981
- Altered acetylcholinesterase isozyme patterns in mice with hereditary muscular dystrophy. Journal of Experimental Zoology. 216:213-223. 1981
- Bovine pituitary Fibroblast Growth Factor has neurotrophic activity on newt limb regenerates and skeletal muscles in vitro. Experimental Cell Research. 132:15-21. 1981
- Phloretin-sensitive lithium transport in erythrocytes of affectively ill patients: Intra-individual reproducibility. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 5:503-506. 1981
- Avian chimaeras and the study of neuromuscular development. Trends in Neurosciences. 3:36-38. 1980
- Noradrenaline and cyclic AMP—independent growth stimulation in newt limb blastemata. Nature. 283:387-388. 1980
- Neural regulation of cholinesterase in newt skeletal muscle. I. Distribution and characterization of the enzyme species. Journal of Experimental Zoology. 210:435-450. 1979
- Neural regulation of cholinesterase in newt skeletal muscle. II. The effects of denervation and of culture in vitro. Journal of Experimental Zoology. 210:451-462. 1979
- Neural regulation of cholinesterase in newt skeletal muscle. III. Regulation in vitro by proteins from chick embryo brains. Journal of Experimental Zoology. 210:463-472. 1979
- The effect of membrane cholesterol depletion upon erythrocyte membrane-bound enzymes. Biochemistry and Cell Biology. 57:1144-1152. 1979
- Myotonic muscular dystrophy. Neurology. 29:791-791. 1979
- Phosphorylation of casein by human erythrocyte membrane-bound protein kinase: competition of casein with endogenous substrates. Journal of Membrane Biology. 49:123-138. 1979
- DISCUSSION. TECHNICAL NOTE. RELEVANCE OF HAZARD ASSESSMENT AND CONTROL TO PRACTICAL ACCIDENT PREVENTION.. Proceedings of Institution of Civil Engineers: Energy. 66:151-152. 1979
- ROLE OF THE NEURAL TUBE IN THE PATHOGENESIS OF HEREDITARY MUSCULAR DYSTROPHY IN THE CHICKEN: STUDIES WITH TRANSPLANTATION CHIMERAS *. Annals of the New York Academy of Sciences. 317:594-610. 1979
- Alterations of erythrocyte ghost protein phosphorylation in the duchenne and myotonic muscular dystrophies. Molecular Genetics and Metabolism. 20:434-439. 1978
- Nerve trophic effects: An in vitro assay for factors involved in regulation of protein synthesis in regenerating amphibian limbs. Journal of Experimental Zoology. 206:347-354. 1978
- Alterations of Membrane Phosphorylation in Erythrocyte Membranes from Patients with Duchenne Muscular Dystrophy. Canadian Journal of Neurological Sciences. 5:437-442. 1978
- Chimaera studies of the origin and formation of the pectoral musculature of the avian embryo. Journal of Experimental Zoology. 205:321-326. 1978
- Altered lipoprotein composition and elevated serum lipids in chicken embryos with hereditary muscular dystrophy. Neuroscience Letters. 8:151-158. 1978
- Red-Cell Stability in Duchenne's Syndrome. New England Journal of Medicine. 298:403-403. 1978
- Alterations in erythrocyte membrane material properties: a marker of the membrane abnormality in human and chicken muscular dystrophy.. Progress in Clinical and Biological Research. 20:189-203. 1978
- Factors involved in the stimulation of parasympathetic nerve outgrowth. Developmental Biology. 61:131-139. 1977
- Elevated cholesterol in tissues of chicken embryos with hereditary myotonic muscular dystrophy. Experimental Neurology. 57:475-485. 1977
- Changes in cyclic GMP levels during forelimb regeneration in adult notophthalmus viridescens. Journal of Experimental Zoology. 200:169-175. 1977
- Evidence for a selective stimulation of myosin synthesis following muscle denervation. Experimental Neurology. 52:177-188. 1976
- Dystrophic Spinal Cord Transplants Induce Abnormal Thymidine Kinase Activity in Normal Muscles. Science. 189:1106-1107. 1975
- Stimulation of Nerve Fiber Growth from Cultured Sympathetic Explants. Canadian Journal of Physiology and Pharmacology. 52:840-851. 1974
- Metabolism and biological effects of N 6 -( 2 -isopentenyl)-adenosine on a cell line derived from circulating leukocytes of a patient with chronic myelogenous leukemia.. Cancer Research. 32:1647-1650. 1972
- Concerning the presence of the cytokinin, N 6-(?2-isopentnyl) adenine, in cultures of Corynebacterium fascians. Planta. 108:93-102. 1972