Journal article
Activation of P2X7 Receptors Stimulates the Expression of P2Y2 Receptor mRNA in Astrocytes Cultured from Rat Brain
Abstract
Under pathological conditions brain cells release ATP at concentrations reported to activate P2X(7) ionotropic receptor subtypes expressed in both neuronal and glial cells. In the present study we report that the most potent P2X(7) receptor agonist BzATP stimulates the expression of the metabotropic ATP receptor P2Y(2) in cultured rat brain astrocytes. In other cell types several kinds of stimulation, including stress or injury, induce P2Y(2) …
Authors
D'Alimonte I; Ciccarelli R; Diiorio P; Nargi E; Buccella S; Giuliani P; Rathbone MP; Jiang S; Caciagli F; Ballerini P
Journal
International Journal of Immunopathology and Pharmacology, Vol. 20, No. 2, pp. 301–316
Publisher
SAGE Publications
Publication Date
April 2007
DOI
10.1177/039463200702000210
ISSN
0394-6320