Journal article
Suboptimal monitoring and dosing of unfractionated heparin in comparative studies with low-molecular-weight heparin.
Abstract
BACKGROUND: Site-specific validation of the activated partial thromboplastin time (aPTT) therapeutic range is required to ensure administration of the optimal dose of unfractionated heparin. Therapeutic ranges of 1.5 to 2.5 times the control value are subtherapeutic for most modern aPTT reagents.
PURPOSE: To audit the appropriateness of aPTT monitoring in clinical trials comparing unfractionated heparin and low-molecular-weight heparin in …
Authors
Raschke R; Hirsh J; Guidry JR
Journal
Annals of Internal Medicine, Vol. 138, No. 9, pp. 720–723
Publisher
American College of Physicians
Publication Date
May 6, 2003
DOI
10.7326/0003-4819-138-9-200305060-00008
ISSN
1056-8751