Journal article
Endogenous Glucocorticoid Response to Single-Dose Dexamethasone for Croup in Children: A Pharmacodynamic Study.
Abstract
OBJECTIVES: Dexamethasone is associated with adrenal insufficiency in adults and children with chronic disease. This association has not been studied after single-dose oral dexamethasone, the standard of care for children with croup. We hypothesized that single-dose oral dexamethasone in children with croup is associated with a transient decrease in endogenous glucocorticoids.
METHODS: We conducted a prospective, 2-arm, pharmacodynamic study of …
Authors
Gill N; Sirizzotti N; Johnson D; Joubert G; Kucey AS; Tieu A; Urquhart BL; Columbus M; Lim R; Rieder M
Journal
Pediatric Emergency Care, Vol. Publish Ahead of Print, No. 1, pp. 50–56
Publisher
Wolters Kluwer
Publication Date
January 2020
DOI
10.1097/pec.0000000000001142
ISSN
0749-5161