Cognitive Decline in a Colombian Kindred With Autosomal Dominant Alzheimer Disease: A Retrospective Cohort Study

Abstract

IMPORTANCE: Data from an autosomal dominant Alzheimer disease (ADAD) kindred were used to track the longitudinal trajectory of cognitive decline associated with preclinical ADAD and explore factors that may modify the rate of cognitive decline. OBJECTIVES: To evaluate the onset and rate of cognitive decline during preclinical ADAD and the effect of socioeconomic, vascular, and genetic factors on the cognitive decline.

Authors

Aguirre-Acevedo DC; Lopera F; Henao E; Tirado V; Muñoz C; Giraldo M; Bangdiwala SI; Reiman EM; Tariot PN; Langbaum JB

Journal

JAMA Neurology, Vol. 73, No. 4,

Publisher

American Medical Association (AMA)

Publication Date

April 1, 2016

DOI

10.1001/jamaneurol.2015.4851

ISSN

2168-6149

Associated Experts

Shrikant Bangdiwala

Professor, Faculty of Health Sciences

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