Recombination, mutation, or constitutive expression at a Gm locus and familial hypergammaglobulinemia. Journal Articles uri icon

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  • In a hypercholesterolemic Lebanese family, an uncommon Gm haplotype carrying an unexpected C gamma 1 gene was inherited by only one of 10 siblings. A new recombination during the maternal or paternal meiosis could explain its formation. According to this hypothesis, our data would be informative for the linkage relationship between the gamma-cistrons and the alpha 2-cistron. The latter might be located near the N-terminal side of the gamma-cistron linkage group, and the sequence of genes would be alpha 2, gamma 4, gamma 3, and gamma 1. A mutation could also effect the change from G1m(17) (codons AAA and AAG) TO G1m(3) (codons AGA and AGG). Another alternative is to postulate a constitutive expression of a C gamma 1 structural gene which, normally, would not be expressed. The uncommon derepression could be the consequence of uncommon cellular response to environmental, pathological or metabolic perturbation of a regulatory mechanism.


  • Lefranc, G
  • Rivat, L
  • Salier, JP
  • van Loghem, E
  • Aydenian, H
  • Zalzal, Paul
  • Chakhachiro, L
  • Loiselet, J
  • Ropartz, C

publication date

  • September 1977