Helicobacter pylori augments the pH-increasing...

Helicobacter pylori augments the pH-increasing effect of omeprazole in patients with duodenal ulcer

Abstract

BACKGROUND & AIMS: Omeprazole is less effective in healthy subjects than in patients with duodenal ulcers. The aim of this study was to determine whether Helicobacter pylori augments the pH-increasing effect of omeprazole in patients with duodenal ulcers. METHODS: In 16 patients with duodenal ulcers, baseline intragastric acidity was measured before and 4-6 weeks after the cure of H. pylori infection. In 17 patients with duodenal ulcers, 24-hour pH metry was performed during treatment with 20 mg omeprazole once daily before as well as after eradication of H. pylori. Intragastric acidity was measured using a glass electrode placed 5 cm below the cardia. H. pylori infection was assessed by [13C] urea breath test, culture, histology, and rapid urease test. RESULTS: H. pylori eradication resulted in marked decrease of the pH-increasing effect of omeprazole (24-hour median gastric pH, 5.5 vs. 3.0; P<0.002) that was most pronounced during nighttime (median gastric pH, 6.4 vs. 2.1; P=0.001). On the other hand, baseline intragastric pH remained unchanged after eradication (median gastric pH, 1.0 vs. 1.1; P=0.5). CONCLUSIONS: In patients with duodenal ulcers treated with omeprazole, intragastric pH depends significantly on the presence or absence of H. pylori, whereas baseline pH remained unchanged after H. pylori eradication.

Authors

Labenz J; Tillenburg B; Peitz U; Idstrom J; Verdu E; Stolte M; Borsch G; Blum A

Journal

Gastroenterology, Vol. 110, No. 3, pp. 725–732

Publisher

Elsevier

Publication Date

January 1, 1996

DOI

10.1053/gast.1996.v110.pm8608881

ISSN

0016-5085

Associated Experts

Elena Verdu

Professor, FHSMED

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