Journal article
Novel Role of the Serine Protease Inhibitor Elafin in Gluten-Related Disorders
Abstract
OBJECTIVES: Elafin, an endogenous serine protease inhibitor, modulates colonic inflammation. We investigated the role of elafin in celiac disease (CD) using human small intestinal tissues and in vitro assays of gliadin deamidation. We also investigated the potential beneficial effects of elafin in a mouse model of gluten sensitivity.
METHODS: Epithelial elafin expression in the small intestine of patients with active CD, treated CD, and …
Authors
Galipeau HJ; Wiepjes M; Motta J-P; Schulz JD; Jury J; Natividad JM; Pinto-Sanchez I; Sinclair D; Rousset P; Martin-Rosique R
Journal
The American Journal of Gastroenterology, Vol. 109, No. 5,
Publisher
Wolters Kluwer
Publication Date
5 2014
DOI
10.1038/ajg.2014.48
ISSN
0002-9270
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultAnimalsBiomarkersCase-Control StudiesCeliac DiseaseChromatography, LiquidDeaminationDiet, Gluten-FreeElafinFemaleGTP-Binding ProteinsGliadinHumansIntestinal MucosaIntestine, SmallMaleMass SpectrometryMiceMice, Inbred NODMiddle AgedPermeabilityProtein Glutamine gamma Glutamyltransferase 2TransglutaminasesZonula Occludens-1 Protein