Impaired hydrogen sulfide synthesis and IL-10 signaling underlie hyperhomocysteinemia-associated exacerbation of colitis Journal Articles uri icon

  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All


  • Significance Inflammatory bowel diseases (IBDs) are debilitating conditions with no known cure. Recent evidence suggests that elevated intestinal hydrogen sulfide (H 2 S) synthesis promotes healing and reduces inflammation. H 2 S is synthesized from cysteine largely via vitamin B 6 -dependent enzymes. People with IBD are also at increased risk of hyperhomocysteinemia, a condition that is often caused by vitamin B deficiency. Dietary induction of vitamin B deficiency markedly increased serum homocysteine levels and worsened colitis in rodents. The latter was due to the absence of the typical injury-induced elevation of H 2 S synthesis. Interleukin-10 plays a key role in increasing H 2 S synthesis, attenuating the severity of colitis, and reducing serum homocysteine levels. The H 2 S–interleukin 10 axis may be a viable target for therapy of IBD.


  • Flannigan, Kyle L
  • Agbor, Terence A
  • Blackler, Rory W
  • Kim, Janice J
  • Khan, Waliul
  • Verdu, Elena
  • Ferraz, Jose GP
  • Wallace, John L

publication date

  • September 16, 2014