Journal article
Impaired hydrogen sulfide synthesis and IL-10 signaling underlie hyperhomocysteinemia-associated exacerbation of colitis
Abstract
Vitamin B deficiencies, which can lead to hyperhomocysteinemia (Hhcy), are commonly reported in patients with inflammatory bowel disease (IBD) and may be a causative underlying factor. However, the mechanism for this effect is not known. Hydrogen sulfide (H2S) is a gaseous mediator that promotes tissue repair and resolution of inflammation. In experimental colitis, a marked increase in colonic H2S synthesis drives ulcer healing and resolution …
Authors
Flannigan KL; Agbor TA; Blackler RW; Kim JJ; Khan WI; Verdu EF; Ferraz JGP; Wallace JL
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, No. 37, pp. 13559–13564
Publisher
Proceedings of the National Academy of Sciences
Publication Date
September 16, 2014
DOI
10.1073/pnas.1413390111
ISSN
0027-8424