Journal article
Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-κB and NFAT transcriptional pathways
Abstract
Cyclooxygenase-2 (COX-2) is an inducible enzyme that drives inflammation and is the therapeutic target for widely used nonsteroidal antiinflammatory drugs (NSAIDs). However, COX-2 is also constitutively expressed, in the absence of overt inflammation, with a specific tissue distribution that includes the kidney, gastrointestinal tract, brain, and thymus. Constitutive COX-2 expression is therapeutically important because NSAIDs cause …
Authors
Kirkby NS; Chan MV; Zaiss AK; Garcia-Vaz E; Jiao J; Berglund LM; Verdu EF; Ahmetaj-Shala B; Wallace JL; Herschman HR
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, No. 2, pp. 434–439
Publisher
Proceedings of the National Academy of Sciences
Publication Date
January 12, 2016
DOI
10.1073/pnas.1517642113
ISSN
0027-8424