Iron-Catalyzed Cross-Coupling Reactions between a Bicyclic Alkenyl Triflate and Grignard Reagents Academic Article uri icon

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abstract

  • Fe-catalyzed cross-coupling reactions between a bicyclic alkenyl triflate and Grignard reagents were investigated. Under the optimized reaction conditions, various 2-substituted bicyclic alkenes were synthesized in moderate to excellent yields (52-93%). This method provided an efficient route for the synthesis of 2-substituted bicyclic alkenes with secondary alkyl groups which cannot be synthesized using previous methods such as Pd-catalyzed coupling reactions and lithium-halide exchange reactions.

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publication date

  • October 3, 2008