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Comparative safety and effectiveness of serotonin...
Journal article

Comparative safety and effectiveness of serotonin receptor antagonists in patients undergoing chemotherapy: a systematic review and network meta-analysis

Abstract

BackgroundAlthough serotonin (5-HT3) receptor antagonists are effective in reducing nausea and vomiting, they may be associated with increased cardiac risk. Our objective was to examine the comparative safety and effectiveness of 5-HT3 receptor antagonists (e.g., dolasetron, granisetron, ondansetron, palonosetron, tropisetron) alone or combined with steroids for patients undergoing chemotherapy.MethodsWe searched MEDLINE, Embase, and the …

Authors

Tricco AC; Blondal E; Veroniki AA; Soobiah C; Vafaei A; Ivory J; Strifler L; Cardoso R; Reynen E; Nincic V

Journal

BMC Medicine, Vol. 14, No. 1,

Publisher

Springer Nature

Publication Date

12 2016

DOI

10.1186/s12916-016-0761-9

ISSN

1741-7015