Glial fibrillary acidic protein expression after electroconvulsive shocks in rat brain Academic Article uri icon

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abstract

  • OBJECTIVE: The aim of the present study was to assess the effect of electroconvulsive shock (ECS) in glial fibrillary acidic protein (GFAP) expression in rat brain. METHODS: Rats were given either a single (acute) or a series of eight (chronic) ECS. Brain regions were isolated and levels of glial fibrillary acidic protein (GFAP) in the brain tissue (cortex, hippocampus, and cerebellum) were assessed using an enzyme-linked immunosorbent assay (ELISA). RESULTS: We showed that GFAP expression is reduced in the hippocampus within 48 h and 7 days after acute ECS. GFAP levels are increased in the cerebellum immediately after acute and chronic ECS. No changes were observed in the cortex. CONCLUSIONS: Our findings showed a differential effect of acute and chronic ECS in the astroglial response in the brain of rats.

authors

  • Ceresér, Keila M
  • Frey, Benício N
  • Bernardes, Fernanda B
  • Costa, Sabrina C
  • Andreazza, Ana C
  • Feier, Gustavo
  • Souza, Daniela
  • Tramontina, Francine
  • Gonçalves, Carlos A
  • Kapczinski, Flavio
  • Quevedo, João

publication date

  • June 2006