Journal article
Changes in Antioxidant Defense Enzymes after d-amphetamine Exposure: Implications as an Animal Model of Mania
Abstract
Studies have demonstrated that oxidative stress is associated with amphetamine-induced neurotoxicity, but little is known about the adaptations of antioxidant enzymes in the brain after amphetamine exposure. We studied the effects of acute and chronic amphetamine administration on superoxide dismutase (SOD) and catalase (CAT) activity, in a rodent model of mania. Male Wistar rats received either a single IP injection of d-amphetamine (1 mg/kg, …
Authors
Frey BN; Valvassori SS; Réus GZ; Martins MR; Petronilho FC; Bardini K; Dal-Pizzol F; Kapczinski F; Quevedo J
Journal
Neurochemical Research, Vol. 31, No. 5, pp. 699–703
Publisher
Springer Nature
Publication Date
5 2006
DOI
10.1007/s11064-006-9070-6
ISSN
0364-3190