Journal article
Chronic Administration of Ketamine Elicits Antidepressant‐Like Effects in Rats without Affecting Hippocampal Brain‐Derived Neurotrophic Factor Protein Levels
Abstract
A growing body of evidence has pointed to the blockade of the N-methyl-d-aspartate (NMDA) receptor signaling as a potential therapeutic target for the treatment of major depression. The present study was aimed to evaluate behavioural and molecular effects of the chronic treatment with ketamine and imipramine in rats. To this aim, rats were 14 days treated once a day with ketamine (5, 10 and 15 mg/kg) and imipramine (10, 20 and 30 mg/kg) and …
Authors
Garcia LS; Comim CM; Valvassori SS; Réus GZ; Andreazza AC; Stertz L; Fries GR; Gavioli EC; Kapczinski F; Quevedo J
Journal
Basic & Clinical Pharmacology & Toxicology, Vol. 103, No. 6, pp. 502–506
Publisher
Wiley
Publication Date
December 2008
DOI
10.1111/j.1742-7843.2008.00210.x
ISSN
1742-7835