Journal article
Ketamine treatment reverses behavioral and physiological alterations induced by chronic mild stress in rats
Abstract
Several studies have supported the idea that ionotropic glutamate N-methyl-d-aspartate receptor (NMDA) is an important player in the etiology of psychopathologies, such as anxiety disorders and major depression. Additionally, studies have shown that ketamine induces antidepressant effects in humans as well as in rodents subjected to animal models of depression. In this context, the present study was aimed to evaluate behavioral and …
Authors
Garcia LSB; Comim CM; Valvassori SS; Réus GZ; Stertz L; Kapczinski F; Gavioli EC; Quevedo J
Journal
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 33, No. 3, pp. 450–455
Publisher
Elsevier
Publication Date
April 2009
DOI
10.1016/j.pnpbp.2009.01.004
ISSN
0278-5846
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adrenal GlandsAdrenocorticotropic HormoneAnimalsBehavior, AnimalCorticosteroneDisease Models, AnimalDrug Administration ScheduleEatingExcitatory Amino Acid AntagonistsExploratory BehaviorFood DeprivationFood PreferencesKetamineLocomotionMaleRatsRats, WistarRestraint, PhysicalSocial IsolationStress, PsychologicalTime FactorsWater Deprivation