Journal article
Acute harmine administration induces antidepressive-like effects and increases BDNF levels in the rat hippocampus
Abstract
Harmine is a beta-carboline alkaloid that inhibits monoamine reuptake systems. Findings point to an antidepressant effect of the compounds that increases the levels of monoamines after monoamine oxidase inhibition. The present study aims to compare the behavioral effects and the BDNF hippocampus levels of acute administration of harmine and imipramine in rats. To this aim, rats were acutely treated with harmine (5, 10 and 15 mg/kg) and …
Authors
Fortunato JJ; Réus GZ; Kirsch TR; Stringari RB; Stertz L; Kapczinski F; Pinto JP; Hallak JE; Zuardi AW; Crippa JA
Journal
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 33, No. 8, pp. 1425–1430
Publisher
Elsevier
Publication Date
November 2009
DOI
10.1016/j.pnpbp.2009.07.021
ISSN
0278-5846