Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania Journal Articles uri icon

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  • Cannabidiol (CBD), a Cannabis sativa constituent, may present a pharmacological profile similar to mood stabilizing drugs, in addition to anti-oxidative and neuroprotective properties. The present study aims to directly investigate the effects of CBD in an animal model of mania induced by d-amphetamine (d-AMPH). In the first model (reversal treatment), rats received saline or d-AMPH (2 mg/kg) once daily intraperitoneal (i.p.) for 14 days, and from the 8th to the 14th day, they were treated with saline or CBD (15, 30 or 60 mg/kg) i.p. twice a day. In the second model (prevention treatment), rats were pretreated with saline or CBD (15, 30, or 60 mg/kg) regime i.p. twice a day, and from the 8th to the 14th day, they also received saline or d-AMPH i.p. once daily. In the hippocampus CBD (15 mg/kg) reversed the d-AMPH-induced damage and increased (30 mg/kg) brain-derived neurotrophic factor (BDNF) expression. In the second experiment, CBD (30 or 60 mg/kg) prevented the d-AMPH-induced formation of carbonyl group in the prefrontal cortex. In the hippocampus and striatum the d-AMPH-induced damage was prevented by CBD (15, 30 or 60 mg/kg). At both treatments CBD did not present any effect against d-AMPH-induced hyperactivity. In conclusion, we could not observe effects on locomotion, but CBD protect against d-AMPH-induced oxidative protein damage and increased BDNF levels in the reversal model and these effects vary depending on the brain regions evaluated and doses of CBD administered.


  • Valvassori, Samira S
  • Elias, Guilherme
  • de Souza, Bruna
  • Petronilho, Fabrícia
  • Dal-Pizzol, Felipe
  • Kapczinski, Flavio
  • Trzesniak, Clarissa
  • Tumas, Vitor
  • Dursun, Serdar
  • Nisihara Chagas, Marcos Hortes
  • Hallak, Jaime EC
  • Zuardi, Antonio W
  • Quevedo, João
  • Crippa, José AS

publication date

  • February 2011

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