Ketamine alters behavior and decreases BDNF levels in the rat brain as a function of time after drug administration Academic Article uri icon

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abstract

  • OBJECTIVE: To evaluate behavioral changes and brain-derived neurotrophic factor (BDNF) levels in rats subjected to ketamine administration (25 mg/kg) for 7 days. METHOD: Behavioral evaluation was undertaken at 1 and 6 hours after the last injection. RESULTS: We observed hyperlocomotion 1 hour after the last injection and a decrease in locomotion after 6 hours. Immobility time was decreased and climbing time was increased 6 hours after the last injection. BDNF levels were decreased in the prefrontal cortex and amygdala when rats were killed 6 hours after the last injection, compared to the saline group and to rats killed 1 hour after the last injection. BDNF levels in the striatum were decreased in rats killed 6 hours after the last ketamine injection, and BDNF levels in the hippocampus were decreased in the groups that were killed 1 and 6 hours after the last injection. CONCLUSION: These results suggest that the effects of ketamine on behavior and BDNF levels are related to the time at which they were evaluated after administration of the drug.

authors

  • Fraga, Daiane B
  • Réus, Gislaine Z
  • Abelaira, Helena M
  • De Luca, Renata D
  • Canever, Leila
  • Pfaffenseller, Bianca
  • Colpo, Gabriela D
  • Kapczinski, Flavio
  • Quevedo, João
  • Zugno, Alexandra I

publication date

  • September 2013