Journal article
Distribution of label after intrathecal administration of 125I-substance P in the rat
Abstract
Despite the widespread use of the intrathecal route for the administration of neuroactive agents, little is known about the penetration of these agents into the spinal cord. In the present study, 125I-substance P was injected via a spinal catheter to the thoracic or sacro-coccygeal spinal cord in the rat (350-400 g) anesthetized with urethane (2.5 g/kg). Spinal cords were removed rapidly at 1 or 10 min after injection and immediately frozen in …
Authors
Cridland RA; Yashpal K; Romita VV; Gauthier S; Henry JL
Journal
Peptides, Vol. 8, No. 2, pp. 213–221
Publisher
Elsevier
Publication Date
March 1987
DOI
10.1016/0196-9781(87)90092-1
ISSN
0196-9781