Journal article
Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat
Abstract
In a previous study it was found that i.t. administration of L-baclofen decreased arterial pressure and heart rate while D-baclofen differentially increased arterial pressure. The objective of the present study was to determine which of these effects was blocked by prior administration of the GABAB receptor antagonist, phaclofen, and whether the effect of one enantiomer of baclofen could be blocked by prior administration of the other. The …
Authors
Yanguo H; Henry JL
Journal
European Journal of Pharmacology, Vol. 196, No. 3, pp. 267–275
Publisher
Elsevier
Publication Date
April 1991
DOI
10.1016/0014-2999(91)90439-w
ISSN
0014-2999