Myoclonic Seizures as a Main Manifestation of Epstein-Barr Virus Infection Academic Article uri icon

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  • A 15-year-old girl with clinical and serologic evidence of active Epstein-Barr virus infection presented with a new onset of myoclonic jerks, confirmed on electroencephalogram (EEG) by generalized polyspike-and-wave epileptiform activity. Family history for juvenile myoclonic epilepsy was negative, and brain magnetic resonance imaging was normal. The myoclonic jerks resolved spontaneously after 5 days, with gradual normalization of the EEG during the ensuing month and since then no resumption over the last 2 years. Previous reports have already linked Epstein-Barr virus infection to opsoclonus-myoclonus syndrome and hypsarrhythmia, but to the best of our knowledge, this is the first presentation of epileptic myoclonic jerks associated with acute Epstein-Barr virus infection. We suggest that acute myoclonic seizures with a transiently abnormal EEG and benign course can be associated with acute Epstein-Barr virus infection. (J Child Neurol 2002;17:446-447).


  • Bassan, Haim
  • Bloch, Aviva Mimouni
  • Mesterman, Ronit
  • Assia, Ayala
  • Harel, Shaul
  • Fattal-Valevski, Aviva

publication date

  • June 2002