Journal article
Genetic Variants in Vitamin D Pathway Genes and Risk of Pancreas Cancer; Results from a Population-Based Case-Control Study in Ontario, Canada
Abstract
Recent studies of 25-hydroxyvitamin D (25(OH)D) levels and pancreas cancer have suggested a potential role of the vitamin D pathway in the etiology of this fatal disease. Variants in vitamin-D related genes are known to affect 25(OH)D levels and function and it is unknown if these variants may influence pancreatic cancer risk. The association between 87 single nucleotide polymorphisms (SNPs) in 11 genes was evaluated within the Ontario Pancreas …
Authors
Anderson LN; Cotterchio M; Knight JA; Borgida A; Gallinger S; Cleary SP
Journal
PLOS ONE, Vol. 8, No. 6,
Publisher
Public Library of Science (PLoS)
Publication Date
2013
DOI
10.1371/journal.pone.0066768
ISSN
1932-6203
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultAgedAged, 80 and overCanadaCase-Control StudiesCholestanetriol 26-MonooxygenaseCytochrome P450 Family 2FemaleGenetic Predisposition to DiseaseHumansLow Density Lipoprotein Receptor-Related Protein-2MaleMiddle AgedPancreatic NeoplasmsPolymorphism, Single NucleotideReceptors, Calcium-SensingRetinoid X Receptor alphaSteroid HydroxylasesVitamin DVitamin D-Binding ProteinVitamin D3 24-HydroxylaseYoung Adult