Journal article
Randomized Trial of Benznidazole for Chronic Chagas’ Cardiomyopathy
Abstract
BACKGROUND: The role of trypanocidal therapy in patients with established Chagas' cardiomyopathy is unproven.
METHODS: We conducted a prospective, multicenter, randomized study involving 2854 patients with Chagas' cardiomyopathy who received benznidazole or placebo for up to 80 days and were followed for a mean of 5.4 years. The primary outcome in the time-to-event analysis was the first event of any of the components of the composite outcome …
Authors
Morillo CA; Marin-Neto JA; Avezum A; Sosa-Estani S; Rassi A; Rosas F; Villena E; Quiroz R; Bonilla R; Britto C
Journal
The New England Journal of Medicine, Vol. 373, No. 14, pp. 1295–1306
Publisher
Massachusetts Medical Society
Publication Date
10 2015
DOI
10.1056/nejmoa1507574
ISSN
0028-4793