Journal article
IL-10R Polymorphisms Are Associated with Very-early-onset Ulcerative Colitis
Abstract
BACKGROUND: Interleukin-10 (IL-10) signaling genes are attractive inflammatory bowel disease (IBD) candidate genes as IL-10 restricts intestinal inflammation, IL-10 polymorphisms have been associated with IBD in genome-wide association studies, and mutations in IL-10 and IL-10 receptor (IL-10R) genes have been reported in immunodeficient children with severe infantile-onset IBD. Our objective was to determine if IL-10R polymorphisms were …
Authors
Moran CJ; Walters TD; Guo C-H; Kugathasan S; Klein C; Turner D; Wolters VM; Bandsma RH; Mouzaki M; Zachos M
Journal
Inflammatory Bowel Diseases, Vol. 19, No. 1, pp. 115–123
Publisher
Oxford University Press (OUP)
Publication Date
January 2013
DOI
10.1002/ibd.22974
ISSN
1078-0998
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdolescentAge of OnsetCase-Control StudiesChildChild, PreschoolCohort StudiesColitis, UlcerativeCrohn DiseaseFemaleFollow-Up StudiesGenetic Association StudiesGenetic Predisposition to DiseaseHumansInfantInfant, NewbornInterleukin-10Interleukin-10 Receptor alpha SubunitInterleukin-10 Receptor beta SubunitMutationPhosphorylationPolymorphism, Single NucleotidePrognosisRNA Splice SitesSTAT3 Transcription Factor