Endovascular Shear Strain Elastography for the Detection and Characterization of the Severity of Atherosclerotic Plaques: In Vitro Validation and In Vivo Evaluation Journal Articles uri icon

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  • This work explores the potential of shear strain elastograms to identify vulnerable atherosclerotic plaques. The Lagrangian speckle model estimator (LSME) elasticity imaging method was further developed to estimate shear strain elasticity (SSE). Three polyvinyl alcohol cryogel vessel phantoms were imaged with an intravascular ultrasound (IVUS) scanner. The estimated SSE maps were validated against finite-element results. Atherosclerosis was induced in carotid arteries of eight Sinclair mini-pigs using a combination of surgical techniques, diabetes and a high-fat diet. IVUS images were acquired in vivo in 14 plaques before euthanasia and histology. All plaques were characterized by high magnitudes in SSE maps that correlated with American Heart Association atherosclerosis stage classifications (r = 0.97, p < 0.001): the worse the plaque condition the higher was the absolute value of SSE, i.e. |SSE| (e.g., mean |SSE| was 3.70 ± 0.40% in Type V plaques, whereas it was reduced to 0.11 ± 0.01% in normal walls). This study indicates the feasibility of using SSE to highlight atherosclerotic plaque vulnerability characteristics.


  • Majdouline, Younes
  • Ohayon, Jacques
  • Keshavarz Motamed, Zahra
  • Roy Cardinal, Marie-Hélène
  • Garcia, Damien
  • Allard, Louise
  • Lerouge, Sophie
  • Arsenault, Frédéric
  • Soulez, Gilles
  • Cloutier, Guy

publication date

  • May 2014