Journal article
Mathematical model of the role of intercellular signalling in intercellular cooperation during tumorigenesis
Abstract
OBJECTIVES: Intercellular cooperation has been hypothesized to enhance cell proliferation during cancer metastasis through autocrine signalling cascades and mathematical models can provide valuable insights into underlying mechanisms of metastatic tumorigenesis. Here, we present a model that incorporates signal-stimulated cell proliferation, and investigate influences of diffusion-driven heterogeneity in signal concentration on proliferation …
Authors
Ghosh S; Elankumaran S; Puri IK
Journal
Cell Proliferation, Vol. 44, No. 2, pp. 192–203
Publisher
Wiley
Publication Date
April 2011
DOI
10.1111/j.1365-2184.2011.00739.x
ISSN
0960-7722