Regulation of apolipoprotein B biogenesis in human hepatocytes: Posttranscriptional control mechanisms that determine the hepatic production of apolipoprotein B-containing lipoproteins

OBJECTIVES: Hepatic overproduction of apolipoprotein B (apoB)-containing lipoproteins appears to be a common cause of hyperlipoproteinemia in humans. Patients with overproduction states secrete denser cholesterol ester-rich lipoprotein particles which are highly atherogenic. The formation of apoB particles involves a very complex process that requires the coordinated synthesis and assembly of apoB, triglycerides, cholesterol esters, …