Journal article
Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial
Abstract
BACKGROUND: Trials of beta blockers in patients undergoing non-cardiac surgery have reported conflicting results. This randomised controlled trial, done in 190 hospitals in 23 countries, was designed to investigate the effects of perioperative beta blockers.
METHODS: We randomly assigned 8351 patients with, or at risk of, atherosclerotic disease who were undergoing non-cardiac surgery to receive extended-release metoprolol succinate (n=4174) or …
Authors
Devereaux PJ; Yang H; Yusuf S; Guyatt G; Leslie K; Villar JC; Xavier D; Chrolavicius S; Greenspan L; Pogue J
Journal
The Lancet, Vol. 371, No. 9627, pp. 1839–1847
Publisher
Elsevier
Publication Date
May 2008
DOI
10.1016/s0140-6736(08)60601-7
ISSN
0140-6736