Journal article
The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice
Abstract
BACKGROUND & AIMS: Alterations in the microbial composition of the gastrointestinal tract (dysbiosis) are believed to contribute to inflammatory and functional bowel disorders and psychiatric comorbidities. We examined whether the intestinal microbiota affects behavior and brain biochemistry in mice.
METHODS: Specific pathogen-free (SPF) BALB/c mice, with or without subdiaphragmatic vagotomy or chemical sympathectomy, or germ-free BALB/c mice …
Authors
Bercik P; Denou E; Collins J; Jackson W; Lu J; Jury J; Deng Y; Blennerhassett P; Macri J; McCoy KD
Journal
Gastroenterology, Vol. 141, No. 2, pp. 599–609.e3
Publisher
Elsevier
Publication Date
August 2011
DOI
10.1053/j.gastro.2011.04.052
ISSN
0016-5085