Journal article
Tracking gastrointestinal transit of solids in aged rats as pharmacological models of chronic dysmotility
Abstract
BACKGROUND: Dysmotility in the gastrointestinal (GI) tract often leads to impaired transit of luminal contents leading to symptoms of diarrhea or constipation. The aim of this research was to develop a technique using high resolution X-ray imaging to study pharmacologically induced aged rat models of chronic GI dysmotility that mimic accelerated transit (diarrhea) or constipation. The 5-hydroxytryptamine type 4 (5-HT4 ) receptor agonist …
Authors
Dalziel JE; Young W; Bercik P; Spencer NJ; Ryan LJ; Dunstan KE; Lloyd-West CM; Gopal PK; Haggarty NW; Roy NC
Journal
Neurogastroenterology & Motility, Vol. 28, No. 8, pp. 1241–1251
Publisher
Wiley
Publication Date
8 2016
DOI
10.1111/nmo.12824
ISSN
1350-1925