Journal article
The efect of indornethacin‐induced gastric rnucosal injury on 24‐h intragastric acidity and plasma gastrin concentration in healthy volunteers
Abstract
AIMS: To determine the influences of prostaglandin inhibition by indomethacin on 24-h intragastric acidity and plasma gastrin concentration, related to gastric mucosal injury.
METHODS: A pre- and post-treatment study design was employed in 10 Helicobacter pylori negative healthy male subjects. All subjects underwent upper gastrointestinal endoscopy at least 3 days before and after 7 days dosing with indomethacin 50 mg t.d.s. Mucosal damage was …
Authors
RADEMAKER JW; RAINSFORD KD; STETSKO PI; JOHNSON DM; CHIBA N; MCDONALD TM; HUNT RH
Journal
Alimentary Pharmacology & Therapeutics, Vol. 9, No. 6, pp. 625–631
Publisher
Wiley
Publication Date
December 1995
DOI
10.1111/j.1365-2036.1995.tb00431.x
ISSN
0269-2813