Journal article
Isolation and Characterization of Human Monoclonal Antibodies from Individuals Infected with West Nile Virus
Abstract
Monoclonal antibodies (MAbs) neutralizing West Nile Virus (WNV) have been shown to protect against infection in animal models and have been identified as a correlate of protection in WNV vaccine studies. In the present study, antibody repertoires from three convalescent WNV-infected patients were cloned into an scFv phage library, and 138 human MAbs binding to WNV were identified. One hundred twenty-one MAbs specifically bound to the viral …
Authors
Throsby M; Geuijen C; Goudsmit J; Bakker AQ; Korimbocus J; Kramer RA; der Horst MC-V; de Jong M; Jongeneelen M; Thijsse S
Journal
Journal of Virology, Vol. 80, No. 14, pp. 6982–6992
Publisher
American Society for Microbiology
Publication Date
July 15, 2006
DOI
10.1128/jvi.00551-06
ISSN
0022-538X