Journal article
Interaction between LSD and dopamine D2/3 binding sites in pig brain
Abstract
The psychoactive properties of the hallucinogen LSD have frequently been attributed to high affinity interactions with serotonin 5HT2 receptors in brain. Possible effects of LSD on dopamine D2/3 receptor availability have not previously been investigated in living brain. Therefore, we used PET to map the binding potential (pB) of [11C]raclopride in brain of three pigs, first in a baseline condition, and again at 1 and 4 h after administration …
Authors
Minuzzi L; Nomikos GG; Wade MR; Jensen SB; Olsen AK; Cumming P
Journal
Synapse, Vol. 56, No. 4, pp. 198–204
Publisher
Wiley
Publication Date
June 15, 2005
DOI
10.1002/syn.20141
ISSN
0887-4476
Fields of Research (FoR)
Medical Subject Headings (MeSH)
3,4-Dihydroxyphenylacetic AcidAnalysis of VarianceAnimalsAutoradiographyBinding SitesBrainBrain MappingCarbon IsotopesDopamineDopamine AntagonistsDose-Response Relationship, DrugFemaleHomovanillic AcidLysergic Acid DiethylamideMicrodialysisPositron-Emission TomographyRacloprideReceptors, Dopamine D2Receptors, Dopamine D3Serotonin Receptor AgonistsSwineTime Factors