Journal article
The Effects of Low-intensity Warfarin on Coagulation Activation in Patients with Antiphospholipid Antibodies and Systemic Lupus Erythematosus
Abstract
The optimal intensity of oral anticoagulant therapy for the prevention of thromboembolism in patients with antiphospholipid antibodies (APLA) and systemic lupus erythematosus is controversial. Retrospective studies have suggested that patients with APLA are resistant to oral anticoagulant therapy, with a targeted International Normalization Ratio (INR) of 2.0 to 3.0, and that a higher intensity of anticoagulation (INR: 2.6 to 4.5) is required …
Authors
Douketis JD; Crowther MA; Julian JA; Stewart K; Donovan D; Kaminska EA; Laskin CA; Ginsberg JS
Journal
Thrombosis and Haemostasis, Vol. 82, No. 03, pp. 1028–1032
Publisher
Thieme
Publication Date
1999
DOI
10.1055/s-0037-1614324
ISSN
0340-6245