Journal article
Randomized, Prospective, Controlled Study Comparing Radical Prostatectomy Alone and Neoadjuvant Androgen Withdrawal in the Treatment of Localized Prostate Cancer
Abstract
PURPOSE: A prospective, multicenter, randomized study was done to test the hypothesis that neoadjuvant androgen withdrawal decreases the incidence of positive margins following radical prostatectomy for localized prostate cancer.
MATERIALS AND METHODS: Observations were made of 213 patients randomized to undergo radical prostatectomy alone (101) or to receive a 12-week course of 300 mg. cyproterone acetate daily followed by surgery (112). …
Authors
Goldenberg SL; Klotz LH; Srigley J; Jewett MAS; Mador D; Fradet Y; Barkin J; Chin J; Paquin J-M; Bullock MJ
Journal
Journal of Urology, Vol. 156, No. 3, pp. 873–877
Publisher
Wolters Kluwer
Publication Date
September 1996
DOI
10.1016/s0022-5347(01)65645-3
ISSN
0021-0005