Efficacy of substituting innovator propafenone for its generic formulation in patients with atrial fibrillation Journal Articles uri icon

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  • The clinical outcomes of 114 patients with atrial fibrillation who had been treated with the innovator propafenone, and in whom the drug was then replaced with generic propafenone because of cost containment, were compared. The generic formulation was found to be at least as safe and effective as the innovator drug, with regard to atrial fibrillation recurrence, emergency room and hospital admissions, and necessity for concomitant therapy.


  • Amit, Guy
  • Rosen, Amit
  • Wagshal, Avraham B
  • Bonneh, Dan Y
  • Liss, Tzvika
  • Grosbard, Aviva
  • Ilia, Reuven
  • Katz, Amos

publication date

  • June 2004