Journal article
Transplant immunosuppression enhances efficiency of adenoviral-mediated gene retransfection: inhibition of interferon-γ and immunoglobin G
Abstract
BACKGROUND: Transplant immunosuppression regimen facilitates successful adenovirus-mediated gene transfection and retransfection in the rat lung. Herein, we investigated the effect of this strategy on circulating cytokines and antiadenoviral immunoglobin G antibody.
METHODS: Male Lewis rats were transfected with 1 x 10(9) pfu/mL of E1-deleted Ad5CMVLacZ vector transtracheally. Rats were randomly assigned to receive daily intraperitoneal triple …
Authors
Suga M; Gladdy R; Xing Z; Keshavjee SH; Liu M
Journal
The Annals of Thoracic Surgery, Vol. 73, No. 4, pp. 1092–1097
Publisher
Elsevier
Publication Date
4 2002
DOI
10.1016/s0003-4975(01)03574-3
ISSN
0003-4975
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdenoviridaeAnimalsAntibodies, ViralAzathioprineCyclosporineDrug Therapy, CombinationGene ExpressionGenetic VectorsImmunoglobulin GImmunosuppression TherapyImmunosuppressive AgentsInterferon-gammaLac OperonMaleMethylprednisoloneRatsRats, Inbred LewRetreatmentTransfectionTransgenesTumor Necrosis Factor-alphabeta-Galactosidase